Hormonal and developmental regulation of the steroidogenic acute regulatory protein.
نویسندگان
چکیده
منابع مشابه
Cloning, Expression and Hormonal Regulation of Steroidogenic Acute Regulatory Protein Gene in Buffalo Ovary
In mammalian ovary, steroidogenic acute regulatory (StAR) protein mediates the true rate-limiting step of transport of cholesterol from outer to inner mitochondrial membrane. Appropriate expression of StAR gene represents an indispensable component of steroidogenesis and its regulation has been found to be species specific. However, limited information is available regarding StAR gene expressio...
متن کاملDevelopmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice.
Steroidogenic acute regulatory protein (StAR) is essential for adrenal and gonadal steroidogenesis, stimulating the translocation of cholesterol to the inner mitochondrial membrane where steroidogenesis commences. StAR mutations in humans cause congenital lipoid adrenal hyperplasia (lipoid CAH), an autosomal recessive condition with severe deficiencies of all classes of steroid hormones. We pre...
متن کاملOxysterols regulate expression of the steroidogenic acute regulatory protein.
The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system, which catalyzes the first enzymatic step in all steroid synthesis. Intriguingly, substrate cholesterol derived from lipoprotein can upregulate StAR gene expression. Moreover, substrate oxysterols have been suggested to also play a role. To investig...
متن کاملThe steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain.
Although recent research has focused on the fundamental role(s) of steroids synthesized de novo in the brain on development, the mechanism by which production of these neurosteroids is regulated remains unclear. Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the in...
متن کاملSteroidogenic Acute Regulatory Protein Expression in the Central Nervous System
Locally produced neurosteroids are proposed to have many functions in the central nervous system. The identification of the steroidogenic acute regulatory protein in steroid-producing neural cells provides a new tool to understand the sites, regulation, and importance of their synthesis.
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1995
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.9.10.8544843